@plantbrain, would you say that a richer substrate with some of the above qualities would be a better substrate than an inert one with just water column fertilization?
Water column can act synergistically with rich sediment. You can go cold turkey and just run rich sediment. There are a few groups that do this every few years but it's never gained much traction, then one or several of them start adding Micros or think the K+ is magic and required with the method. It is not.
I see few good reasons to NOT use a clay sediment like ADA AS.
It makes your tank grow nicer plants with less dependence on the water column.
So either way, it's better to have it.
In some cases for a speciality tank, plain sand only might be a good idea, but these tend to use tough hardy plant, and there might be a hardscape or fish dependence. These are exceptions. I have a few examples like this one. Plants all emergent, white thin layer of sand.
No matter how good your water column dosing is, the fact remains that adding a rich soil will only help more in almost all cases. We can generalize and say this as matter of advice. A few exception perhaps, but very few.