These numbers do not appear to be right when I input them into Rotala Butterfly. Here are my results for 1ml into 10L.
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So If you are adding 1mL to a 10L aquarium your doing result is 2.9681 ppm of NO3. The NPK percentages are close to that of the product when I check on 2hr website.
It depends on your goal. I would recommend a consistent water change weekly. That way you can easily maintain nutrient levels. If you do 50% one week and then 80% another week you will have to dose 30% more nutrients on the week that you did an 80% water change volume to account for the removal of nutrients from the water change. If you do weekly personally I divide my total ppm of nutrients into 4 doses. Doing a double dose after water change and then 2 normal doses during the week. So how that looks for me is Sunday half the total nutirents after water change(50%), Tuesday a quarter of the nutrients (25%), Thursday a quarter of the nutrients (25%) which give me 100% of my nutrients for the week and then water change on Sunday. You want whatever your target ppm for the week divided by the amount of times you want to dose between water changes.
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So lets look at an example if you want to target 15ppm of NO3 during the week then you need to dose a total of 5.1 mL throughtout the week to reach that number. So if you dose that over 4 days you need to dose 1.275 mL for 4 days. You could also do a water change and dose all 5.1 mL but with this being a AIO I would want to break up the Fe dosing throughout the week.
Since you are using APT3 I would base your dose off of NO3, the reason I personally do not like AIO is 1. you are locked into there ratios and 2. you are essentially paying for water. While I love Dennis Wong and what he has done this is true of all AIO products companys make or even individual bottles a certain company makes of individual elements.
I hope this helps. Hopefully I did not confuse you. If you have questions please do not be afraid to respond.